I'm not a huge fan of the animation style, but it kinda worked for what I think you were aiming for. The voice acting was halfway decent, but still not quite there. Lois' voice was very close, and I could actually hear the Stewie pretty well. The only voice I think didn't work very well was Peter, but that's what made it funny.
I wasn't too impressed with the jokes themselves, but the animation reminded me a lot of some of those Saturday Night Live cartoons. Not a bad cartoon, I must say.